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院長紹介

院長

山田泰弘 (やまだやすひろ)

  私立東海高等学校卒業
国立岐阜大学医学部卒業
国立岐阜大学医学部大学院卒業(甲種医学博士号取得)
職歴
  岐阜大学医学部第一内科入局
東京大学医学部大学院(第三内科)国内留学
ブラウン大学医学部留学(アメリカ ロードアイランド州プロビデンス)
ワシントン大学医学部留学(Assistant Research Fellow)(アメリカ ワシントン州シアトル University of Washington)
世界的肝炎研究者のProf. Nelson Faustoのもと肝臓の研究に従事
岐阜大学医学部第一内科、臨床検査医学講師
東海女子短期大学非常勤講師、岐阜県消防学校非常勤講師を併任
賞与
  平成5年上原記念生命科学財団 ポストドクトラルフェローシップ受賞
平成14年 岐阜大学活性化研究会 研究部門 受賞
資格
  医学博士
日本内科学会認定内科認定医
日本消化器病学会認定消化器病専門医
日本消化器内視鏡学会認定消化器内視鏡専門医
日本肝臓学会認定肝臓専門医
日本医師会認定産業医
所属学会
  日本臨床分子医学会(評議員)
日本内科学会
日本消化器病学会
日本消化器内視鏡学会
日本肝臓学会
日本癌学会
日本ビタミン学会
日本分子生物学会
アメリカ肝臓学会(国際会員)
 
≪院長の研究論文≫
Books
  Signalling in the Liver
D. Hausslinger, PC. Heinrich (Eds)
TNF signal transduction during liver regeneration: receptor type 1 but not type 2 is required for hepatocyte replication
N. Fausto, Y. Yamada, I. Kirillova (101-114) Kluwer Academic Publishers, 1998.

Trends in Gastroenterology and Hepatology
H. Asakura, Y. Aoyagi, S. Nakazawa (Eds)
Tumor Necrosis Factor and Liver Regeneration
Y. Yamada, N.Fausto, H. Moriwaki (Part11 Hepatic Regeneration Update, 306-311) Springer-Verlag, 2001.

Publications
  A Case Report of Malignant Fibroma Derived from Omentum Mayor
Shimazaki, M. Yamada, Y. Nagaki, M. Kato, T. Ninomiya, M. Kawai, K. Moriwaki, H. Saito, K. Tomita, E. and Muto, Y.
Japanese Journal of Gastroenterology 86:275-279, 1989.

Differentiation Induction by Acyclic Retinoid
Yamada, Y. Fukutomi, Y. Moriwaki, H. and Muto, Y.
Japanese Journal of Vitaminology 65:343-344, 1991.

Reduced Retinoid Content in Hepatocellular Carcinoma with Special Reference to Alcohol Consumption
Adachi, S. Moriwaki, H. Muto, Y. Yamada, Y. Fukutomi, Y. Shimazaki, M. Okuno,M. and Ninomiya,M.
Hepatology 14 (5):776-780, 1991.

A Giant Brunner's Gland Tumor of the Duodenum Treated by Endoscopic Polypectomy
Onogi, N. Naito, T. Shimazaki, M. Kato, T. Yamada, Y. Kato, M. Kato, T. Ninomiya, M. Moriwaki, H. Muto, Y. Shimokawa, K. Okuno, F. and Sakamoto, Y.
Japanese Gastroendoscopic Journal 5:1235-1238, 1993.

Natural Killer Cell May Impair Liver Regeneration in Fluminant Hepatic Failure
Ohnishi, H. Muto, Y. Maeda, T. Nagaki, M. Yamada, T. Shimazaki, M. Yamada, Y. Sugihara, J. and Moriwaki, H.
Gastroenterologia Japonica 28(4):40-44, 1993.

Positive and Negative Regulations of Albumin Gene Expression by Retinoids in Human Hepatoma Cell Lines.
Yamada, Y. Shidoji, Y. Fukutomi, Y. Ishikawa, T. Kaneko, T. Nakagama, H. Imawari, M. Moriwaki, H. and Muto, Y.
Molecular Carcinogenesis 10(3):151-158, 1994.

Human Papillomavirus Type 16-positive Esophageal Papilloma at an Endoscopic Injection Sclerotherapy Site.
Yamada, Y. Ninomiya, M. Kato, T. Nagaki, M. Kato, M. Hatakeyama, H. Moriwaki, H. and Muto, Y.
Gastroenterology 108(2):550-553, 1995

Induction of Apoptosis by Acyclic Retinoid in the Human Hepatoma-Derived Cell Line, HuH-7
Nakamura, N. Shidoji, Y. Yamada, Y. Hatakeyama, H. Moriwaki, H. and Muto, Y.
Biochem Biophys Res Commun 207(1):382-388, 1995

Retinoid Agonist Activities of Synthetic Geranyl Geranoic Acid Derivatives
Araki, H. Shidoji, Y. Yamada, Y. Moriwaki, H. and Muto, Y.
Biochem Biophys Res Commun 209(1):66-72, 1995

Regulation of Hepatic Genes and Liver Transcription Factors in Rat Hepatocytes by Extracellular Matrix
Nagaki, M. Shidoji, Y. Yamada, Y. Sugiyama, A. Tanaka, M. Akaike, T. Ohnishi, H. Moriwaki, H. and Muto, Y.
Biochem Biophys Res Commun 210(1):38-43, 1995

Intiation of Liver Growth by Tumor Necrosis Factor: Deficient Liver Regeneration in Mice Lacking Type I Tumor Necrosis Factor Receptor
Yamada, Y. Kirillova, I. Peschon, J J. and Fausto, N.
Proc. Natl. Acad. Sci. USA 94(4):1441-1446, 1997

Deficient Liver Regeneration after Carbon Tetrachloride Injury in Mice Lacking Type 1 but not Type 2 Tumor Necrosis Factor Receptor.
Yamada, Y. Fausto, N.
Am. J. Pathol 152(6):1577-1589, 1998

Analysis of Liver Regeneration in Mice Lacking Type 1 or Type 2 Tumor Necrosis Factor Receptor: Requirement for Type 1 but not Type 2 Receptor.
Yamada, Y., Webber E. M., Kirillova, I., Peschon, J. J. and Fausto, N.
Hepatology 28(4):959-970, 1998

Generation of Hepatocytes from Oval Cell Precursors in Culture
Catherine A. Lazaro, Jonathan A. Rhim, Yasuhiro Yamada and Nelson Fausto
Cancer Research 58(23); 5514-5522, 1998

Possible involvement of reactive oxygen species in D-galactosamine-induced sensitization against tumor necrosis factor--induced hepatocyte apoptosis
Yosuke Osawa, Masahito Nagaki, Yoshiko Banno, Yasuhiro Yamada, Motoaki Imose, Yoshinori Nozawa, Hisataka Moriwaki and Shigeru Nakashima
Journal of Cellular Physiology 187(3); 374-385, 2001

L-tryptophan-L-kynurenine pathway metabolism accelerated by Toxoplasma gondii infection is abolished in gamma interferon-gene-deficient mice: cross-regulation between inducible nitric oxide synthase and indoleamine-2,3-dioxygenase.
Fujigaki S, Saito K, Takemura M, Maekawa N, Yamada Y, Wada H, Seishima M.
Infect Immun 2002 Feb;70(2):779-86

Improved myocardial ischemia/reperfusion injury in mice lacking tumor necrosis factor-alpha.
Maekawa N, Wada H, Kanda T, Niwa T, Yamada Y, Saito K, Fujiwara H, Sekikawa K, Seishima M.
J Am Coll Cardiol 2002 Apr 3;39(7):1229-35

Synergistic induction of apoptosis by acyclic retinoid and interferon-beta in human hepatocellular carcinoma cells
Obora, A., Shiratori, Y., Okuno, M., Adachi, S., Takano, Y., Matsushima-Nishiwaki, R., Yasuda, I., Yamada, Y., Akita, K., Sano, T., Shimada, J., Kojima, S., Okano, Y., Friedman, S. L., Moriwaki, H.
Hepatology Nov 36 (5) 1115-24, 2002

TNF-alpha contributes to the development of allergic rhinitis in mice
Iwasaki, M., Saito, K., Takemura, M., Sekikawa, K., Fujii, H., Yamada, Y., Wada, H., Mizuta, K., Seishima, M., Ito, Y.
J Allergy Clin Immunol Jul, 112(1):134-40, 2003

Tumor necrosis factor-alpha from bone marrow-derived cells is not essential for the expression of adhesion molecules in lipopolysaccharide-induced nasal inflammation
Iwasaki, M., Saito, K., Sekikawa, K., Yamada, Y., Wada, H., Mizuta, K., Ito, Y., Seishima, M.
Cytokine 21(3): 129-36, 2003

Lack of interleukin-1beta decreases the severity of atherosclerosis in ApoE-deficient mice
Kirii, H., Niwa, T., Yamada, Y., Wada, H., Saito, K., Iwakura, Y., Asano, M., Moriwaki, H., Seishima, M.
Arterioscler Thromb Vasc Biol 23(4): 656-60, 2003

Genotyping of hepatitis C virus by melting curve analysis with SYBR Green I
Fujigaki, H., Takemura, M., Takahashi, K., Yamada, Y., Fujii, H., Wada, H., Saito, K., Ohnishi, H., Seishima, M.
Ann Clin Biochem 41(2): 130-132, 2004

Role of tumor necrosis factor-alpha in methamphetamine-induced drug dependence and neurotoxicity
Nakajima, A., Yamada, K., Nagai, T., Uchiyama, T., Miyamoto, Y., Mamiya, T., He, J., Nitta, A., Mizuno, M., Tran, M. H., Seto, A., Yoshimura, M., Kitaichi, K., Hasegawa, T., Saito, K., Yamada, Y., Seishima, M., Sekikawa, K., Kim, H. C., Nabeshima, T.
J Neurosci 24(9): 2212-25, 2004

Liver injury induced by lipopolysaccharide is mediated by TNFR-1 but not by TNFR-2 or Fas in mice
Shimizu, S., Yamada, Y., Okuno, M., Ohnishi, H., Osawa, Y., Seishima, M., Moriwaki, H.
Hepatol Res Feb2005

Lack of tumor necrosis factor receptor type 1 inhibits liver fibrosis induced by carbon tetrachloride in mice
Sudo, K., Yamada, Y., Moriwaki, H., Saito, K., Seishima, M.
Cytokine 29(29): 236-44, 2005

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